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apalutamide will decrease the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in decreased publicity to these prescription drugs.Modafinil appeared to produce a